This article provides a guide for recognizing the oral manifestations of select systemic diseases a number of oral manifestations of systemic disease have been covered previously5 6 therefore . Visual survey of surgical pathology with 10925 high quality images of benign and malignant neoplasms related entities oral manifestations of systemic diseases focused oral manifestations of systemic diseases with stained slides of pathology. Many systemic diseases have associated oral symptoms occasionally patients with these diseases present with lesions that occur primarily in the mouth although few systemic diseases have strictly pathognomonic lesions of the oral mucosa a careful examination of the oral cavity can often lend impo . Many systemic diseases have associated oral symptoms occasionally patients with these diseases present with lesions that occur primarily in the mouth although few systemic diseases have strictly pathognomonic lesions of the oral mucosa a careful examination of the oral cavity can often lend important clues to making a diagnosis